Placental accreta is the invasion at different depths of the myometrium by trophoblast that can cause abnormal adhesion. Its incidence increases when there is a placenta previa due to the structure found in the cervix as described in the article of Placenta Previa, or when implanted over a scar from a previous uterine incision or perforation.
The etymology of acretism comes from Latin ac + crescere: to grow from adhesion or coalescence. This abnormal implantation of the placenta is secondary to the partial or total absence of the basal decidua and the imperfect development of the fibrinoid or Nitabuch layer.
What is the incidence of placental accreta?
The incidence of placental accretacy according to the American College of Obstetricians and Gynecologists ACOG is 1 case per 533 births, this has shown that this disease has increased since 1980 where the incidence was of 1 case in every 2,500 deliveries, which informs us that it has increased in frequency. These latest data should alert doctors since pregnant women with placenta accreta, increta or percreta now have a higher morbidity and maternal mortality. In a 2010 review, it reports that of 10,000 maternal deaths in the United States, 8% were due to postpartum hemorrhage secondary to the accretion syndrome.
What is the pathophysiology of placental accreta?
During a normal pregnancy the implantation of the placenta, at a miscroscopic level, it is observed that the placental villi are attached to the decidual cells, but when a pregnant woman presents placental accreta, a junction between these placental villi and the fibers is observed in the histological study. muscles of the uterus, the latter prevents normal placental separation after delivery.
This can be due to a defect in the constitutional endometrium that can be generated by previous traumas such as cesarean, curettage, placenta previa among others.
It must be borne in mind that placental accreta is not only caused by the deficiency of the anatomical layer, but it has also been seen that cytotrophoblasts can control decidual invasion through angiogenesis factors.
How is placental accreta classified?
There are 3 types of placental accreta that differ depending on the depth of invasion of the trophoblast in the uterus.
This is a type of adherence of the placenta that is characterized by the villi are attached to the myometrium, this is presented in 80%, being the most frequent of the three.
Here the villi of the placenta already invade the myometrium, as seen in the image, this type of placenta is presented in 15%.
In this type of placental accretion, the villi have penetrated the entire thickness of the wall of the uterus, reaching the serosa and generating the greatest complications of this disease. The placenta percreta is present in 5%, being the least frequent of the three types of placental accreta.
Abnormal adherence in these three variables can be divided into 2 types: Total accreta placenta that is when there is adherence of all focal lobules and placenta accreta that describe it when a single lobe or part of the lobe of the placenta adheres.
What are the risk factors of placental accreta?
The most important risk factors of pregnant women to present this disease are: Having presented low implantation of the placenta (placenta previa or marginal placenta), having a history of cesarean section, if it presents the two antecedents, is more likely to present the accreta.
Other risk factors are:
Surgical procedures that generate the loss of the basal decidua by scar.
Signs and symptoms of placental accreta
First and second trimesters
The clinic of patients who are in the periods of pregnancy usually there is bleeding as a consequence of the co-existing placenta previa. When the patient does not have vaginal bleeding, her diagnosis is delayed until the third trimester, which by means of ultrasonography (ultrasound) an adherence of the placenta is observed.
How is placental accreta diagnosed?
In order to make the diagnosis of this disease, it is mainly done through transvaginal ultrasound where the infiltration of the placenta in the myometrium can be observed.
The sensitivity of transvaginal ultrasound in placental accreta is between 77 and 87% with a specificity of 96 to 98%, with a positive and negative predictive value of 65 – 98%
Another test that can also be performed is color Doppler that has a high predictive value of myometrial invasion. It can be suspected if the distance between the serous wall and the uterine bladder has retroplacental vessels <1mm and if there are large intraplacental gaps.
For MRI Magnetic Resonance diagnosis, it should be taken into account that it is a complementary examination of transvaginal ultrasound, which should be performed only to identify the anatomy, the degree of invasion and possible ureteral or bladder involvement.
Which is the treatment?
The treatment of acretism is through surgery scheduled after 36 weeks, the treatment must be performed by an obstetrician gynecologist who will define the appropriate management (surgical technique, time of the procedure), and if it can be conservative ( maintain fertility of the woman) or radical (hysterectomy) because it can generate serious adverse consequences such as postpartum hemorrhage.
Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Obstetrical Hemorrhage. Williams Obstetrics, 24e. New York, NY: McGraw-Hill Education; 2013.
Placental abruption is the premature detachment of the placenta, it is divided into a total or partial detachment of the insertion of the placenta before delivery. This disease can occur from 0-4% -1.29% of all pregnancies and has a perinatal mortality of up to 30%. The abrupt placenta can recur between 5.5% and 16.6%.
What are the causes of the detachment of the placenta?
Until today we still do not know exactly what is the etiology of this disease, it is believed that there is an alteration of the decidual and uterine vessels, which adds an arterial hypertension in the mother (occurs in 44% of pregnant women ), generate the rupture of these vessels and triggering a series of steps that are explained later, until the total detachment of the placenta is reached.
There is also a relationship of this entity with the presence of uterine myomatosis, as other risk factors that can be seen in the following image:
What is the pathophysiology of placental abruption?
The detachment of placenta normoinserta occurs in the third trimester of pregnancy, for this reason it is listed as one of the causes of vaginal bleeding in the third trimester (Placenta Previa, Abruptio placenta and placental accreta). It has been described that the cause of this entity is due to the rupture of small vessels that are mostly decidual, this rupture generates a hemorrhage in the basal decidua forming a clot or retroplacental hematoma not evident that causes the placental tissue necrosis, limiting the area of blood exchange between the mother and the fetus, and finally dissecting the placenta until it generates the complete detachment of it.
It must be taken into account that because of the limitation of the blood exchange area, 80% of newborns are preterm and have intrauterine growth restriction (IUGR).
What are the signs and symptoms of placental abruption?
It is important to know that the premature detachment of the placenta is classified as an obstetric emergency, so you must know how to diagnose and treat.
Cardinal abruption of the placenta is a vaginal hemorrhage in the third trimester together with severe pain. This pain occurs because the myometrium contracts to be able to counteract the bleeding but the presence of fetal parts prevents hemostasis, which increases bleeding and this generates more hypertonia (increased tone of the uterus) and tachysystolia (Increased frequency of uterine contractions) becoming a vicious circle.
It must be borne in mind that this retroplacental hemorrhage can be hidden or not hidden, and this depends on the place of the insertion site where the rupture of the vessels occurred as we can see in the following image.
After the hematoma or clot exceeds 500 cc, it extravasates and dissects and infiltrates the myometrium, compromising the uterine tone, forming the so-called Couvelaire Uterus, which can be complicated by disseminated intravascular CID.
How is it classified?
Placental abruption in pregnancy is classified as follows:
Mild, light or grade I: It is characterized by having a detachment of 30% and the fetus is alive.
Moderate, intermediate or grade II: The detachment is between 30-50% and the fetus is still alive.
Severe, severe or grade III: There is a> 50% detachment of the placenta, and a dead fetus
The latter can be divided into a severe placental abruption without disseminated intravascular coagulation or a Abruptio of severe placenta with disseminated intravascular coagulation.
How is placental abruption diagnosed?
Just like everything in medicine, the diagnosis of the premature detachment of the placenta must be initiated through the clinical history where severe pain of sudden onset will be evident, constant that may or may not be accompanied by vaginal bleeding, the latter depends if there is a occult bleeding (20% of patients present, Utero de Couvaliare and irreversible uterine atony) or not.
At the physical examination we can find an increase in the size of the uterus with hypersensitivity, hypertonia and hypesthesia; The amniotic fluid is bloody or in Port Wine; an unsatisfactory fetal state is also present.
What are the complications?
The main complications of placental abruption are:
Ischemic necrosis of distal organs (sd sheehan)
Intrauterine growth retardation IUGR
How should the treatment be?
The following points must be taken into account for their treatment:
Channeling 2 peripheral veins once the patient is channeled, the laboratories should be taken.
Perform a typing and tracking, maintain.
Have continuous maternal-fetal monitoring.
Pass a bladder catheter for the Glomerular Filtration Rate count.
Two special conditions that must be taken into account depending on the number of weeks of gestation of each patient is the realization of an amniotomy and clearing.
Obstetrica de Williams, Edición 22. Capítulo 35. Hemorragias del tercer trimestre.
Texto de Obstetricia y Perinatologia. Universidad Nacional de Colombia. 1999. Dr Jorge Rubio, Dr Heliodoro Ñañez. Capitulo 17, Desprendimiento de la placenta normalmente insertada.
James Alexander, Alison Wortman, Intrapartum Hemorrhage. Obstet Gynecol Clin N Am 40 (2013) 15–26.
Placenta previa refers to implantation of the placenta near the internal cervical os. There are different types of placenta previa: partial placenta previa, complete or total placenta previa, marginal placenta previa and low insertion placenta, which are explained below.
This is one of the most common obstetric complications, and it can cause postpartum hemorrhage during labor.
What is the incidence of placenta previa?
It occurs approximately in 1 of 200 births, but only 20% is total previous placenta. The incidence of placenta previa is 1 in 200 to 1 in 390 pregnant women with gestational age greater than 20 weeks, the frequency of occurrence with deliveries increases, thus for the nulliparous women, the incidence is 0.2%, while in multiparous, it can be greater than 5% and the recurrence rate is 4% to 8%.
What can cause placenta previa?
The causes of abnormal implantation of the placenta are not really known, but hypotheses are established according to uterine and placental causes.
These alter the endometrium or myometrium causing an abnormal implantation of the placenta, such as:
Antecedents of caesarean section
Age: over 35 years
Short intergenic interval
Uterine myomas (myomectomies are four times higher risk)
History of placenta previa (12 times greater probability of presenting a new episode).
The uterine causes that generate the low implantation of the placenta, as for example the antecedent of cesarean section, indicates that the placenta during the gestation process migrates to places of higher arterial perfusion, but when there are scars, it does not allow the migration of the placenta because of the low levels of irrigation that exist in it.
They are those that favor the increase in the size of the placental cake or the implantation surface. A reduction in uterine-placental oxygen promotes the increase in its surface generating an obstruction of the internal cervical os. These placental causes are:
The twin pregnancy
Smoking and cocaine.
What is the Pathophysiology in placenta previa?
It is normal for the placenta to move as the uterus stretches and grows. At the beginning of pregnancy, it is normal for the placenta to be inserted into the lower part of the uterus (or known to patients as the womb). But as the pregnancy progresses, the placenta moves to the top. During the third trimester, the placenta should be close to the fundus, so that the internal cervical os is clear for delivery.
The lower segment is an inadequate region for placental insertion, because it has a thinner endometrium, the decidua is much thinner, altering its vasculature, leading to a more flat and irregular conformation of the placenta, forming partitions between cotyledons, which is associates that the placenta already developed invades the myometrium, the latter is known as placental accreta; The lower segment of the uterus does not contain the same amount of muscle fibers and collagen fibers predominate, there is greater distension and less capacity to collapse the capillaries, generating alterations in the normoinsertion and functioning of the cord, which together trigger lesions in both the fetus and in the mother.
How is placenta previa classified?
There are 4 types of placenta previa that differ depending on the relationship they have with respect to the hole in the cervix.
Complete / Total:
Complete or total placenta previa is characterized by covering the entire internal cervical orifice of the patient
This is the partial placenta previa characterized by covering some percentage of the internal orifice of the cervix.
The location of the placenta is less than 2.5 cm from the edge of the OCI without covering the hole. It is important to bear in mind that marginal placenta previa can generate complications during labor, because the cervix in this period is in the process of dilation and the placenta can obstruct the internal orifice of the cervix, preventing the passage of the fetus to through the birth canal or causing postpartum hemorrhage.
Low Lying Previa This is characterized by being located approximately 3cm from the edge of the OCI. Although in many texts it is not considered within the classification of placenta previa, it can cause the same complications as marginal placenta previa in childbirth, so it should not be forgotten about its existence.
It is important to note that most previous placentas (90%) diagnosed in the middle of pregnancy can be reclassified as normal due to segment formation and uterine growth. Phenomenon called placental migration.
What are the signs and symptoms of placenta previa?
This pathology is part of the group of diseases that make up the hemorrhages of the Third Trimester of Pregnancy. Within the clinic of pregnancy with placenta previa the following symptoms can be highlighted:
This is a vaginal bleeding that occurs in the third trimester of pregnancy, which is characterized by not producing pain, intermittent and bright red.
It is the most important symptom and sign
It is precipitated by the contractions of Braxton-Hicks.
It can be presented before week 30 (30% of cases), between week 30 and 35 (30%), before labor (30%) and during delivery (10%) without previous episodes of bleeding . Up to 10% of cases occur concomitantly with placental abruption (Abruptio of placenta)
The normal course of this first bleeding usually diminishes and disappears, giving time to the correct diagnosis of the present disease.
Subsequent bleeding is considered much more aggressive and of vital commitment.
Related to the weeks of gestation has been found relationship; that the bleeding that occurs before week 28 corresponds to a total occlusion of the placenta and a third of the bleeding occurs in labor. Clinically, the bleeding being 35%, is associated with transverse fetal situations, podal presentation, very high cephalic presentation and soft uterus. A placental murmur can be heard in the hypogastrium.
There is also the maternal risk of secondary hypovolemia that can lead to death due to multiple organ involvement and / or secondary infection.
Regarding fetal compromise, there is an increased risk of intrauterine growth restriction (IUGR) up to 16% due to poor circulation of the uterine segment.
How is placenta previa diagnosed?
The diagnosis of placenta previa can be made by the clinical part based on the patient’s history and pain-free transvaginal bleeding during the second half of pregnancy, the latter being the cardinal sign of this pathology. To confirm the diagnosis, a transvaginal ultrasound should be performed, which evidences the low implantation of the placenta. This examination is considered the Standard GOLD since obstetric ultrasound presents many limitations (maternal obesity, fetal situation, etc).
Therefore, the current classification of placenta previa is as follows:
More than 5 cm from the Internal Cervical Orifice.
Placenta Low Insertion
Between 2 and 5 cm of the Internal Cervical Orifice..
Marginal placenta previa
Less than 2cm from the Internal Cervical Orifice
Placenta Previa Occlusive or partial
0 cm from the Internal Cervical Orifice.
Placenta Previa Total occlusive
Overlap of more than 2 cm.
Placenta previa that persists beyond week 28, has a 20% cause preterm delivery.
What is the Treatment of placenta previa?
The treatment must take into account the degree of bleeding, gestational age, fetal vitality, associated pathologies and whether or not there is labor. Evidence that the treatment can be of two types conservative and of urgency.
However, the objectives of therapy for placenta previa must be taken into account:
Preserve the maternal state.
Preserve the fetal state.
Preserve the maternal state
End all pregnancy greater than 36 weeks
Define the initial hemodynamic state and the estimated blood losses.
Classify the degree of bleeding as mild, moderate or severe
Immediately start resuscitation, with intravenous fluids
Define the need for transfusion
Practice a cesarean, regardless of the gestational age, in case of not achieving control of bleeding.
Preserve the fetal state
Clearly define the gestational age
All pregnancies that were more than 36 weeks old or if fetal lung maturity should be identified.
Order rest in bed until the moment of delivery, if there is control of bleeding.
Manage all patients outpatiently as long as bleeding has been controlled, fetal well-being exists and a paramedic is available to transfer the patient to an institution in case of new bleeding.
Induce pulmonary maturation with corticosteroids as indicated by the lung maturation protocol
Inhibit the uterus if uterine activity occurs, avoiding magnesium sulfate, which has been associated with increased perinatal morbidity.
Follow up ultrasound every three weeks, looking for intrauterine growth restriction and signs of placenta accreta.
Practice weekly amniocentesis to determine the pulmonary maturation profile, starting at week 34.
If the mother is Rh negative, she should receive anti D immunoglobulin.
Blood loss less than 250cc.
More than 36 weeks of gestation and weighing more than 2500 grams.
High level hospital for the management of possible complications.
Lung maturation, uterus inhibition, monitoring of fetal well-being, rest, control of hemoglobin / hematocrit.
Bleeding greater than 250cc
Cesara of urgency
Management of volume losses.
Type of Childbirth
If it is not an obstructive placenta, it can induce labor, taking into account the state of the fetus mother binomial, that is, having a protocol for this type of delivery.
Management of hemorrhage in the third stage
Curettage of the placental bed
Uterine artery embolization.
Application of hemostatic sutures.
Circular sutures in the placental bed.
Uterine or hypogastric ligation
When is caesarean section indicated in placenta previa?
Partial or total placenta previa (TYPE III-IV)
Note: Placenta marginal or low insertion must be evaluated according to the protocols of each institution.
Poor maternal state, Hypovolemic shock
Signs of fetal distress evidenced in fetal monitoring
Maternal: After prenatal bleeding from placenta previa, maternal hemorrhage, shock and death may occur. The patient may also die as a result of hemorrhage during or after childbirth (Red Code), due to operative trauma, infection, embolism or placenta accreta.
Fetal: Prematurity is the cause of 60% of perinatal deaths. The fetus may die as a result of intrauterine anoxia or injury during birth, infant respiratory distress syndrome, hypothermia, hydroelectrolyte alteration, metabolic disturbance, and increased likelihood of neonatal sepsis. Restriction of intrauterine growth (IUGR).
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